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In the current review, we claimed the identification as well as the characterization of a new atypical opioid receptor with distinctive unfavorable regulatory Qualities towards opioid peptides.1 Our effects confirmed that ACKR3/CXCR7, hitherto called an atypical scavenger receptor for chemokines CXCL12 and CXCL11, is likewise a wide-spectrum scaven